Cialis - June 17, 2019

Cialis Com: CIALIS tablets – instructions for use, reviews, descriptions, analogues, release form, photo packaging, side effects, contraindications, price in pharmacies – Health Mail.ru

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Cialis Com: CIALIS tablets - instructions for use, reviews, descriptions, analogues, release form, photo packaging, side effects, contraindications, price in pharmacies - Health Mail.ru

CIALIS tablets – instructions for use, reviews, description, analogs, release form, photo packaging, side effects, contraindications, price in pharmacies – Health Mail.ru

Instructions for use and abstract of the drug, reviews of the drug CIALIS tablets, the minimum cost, photo packaging, analogues CIALIS, side effects, indications for use and contraindications

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The treatment for erectile dysfunction is a reversible selective inhibitor of specific PDE5 cGMP. When sexual arousal causes a local release of nitric oxide, the inhibition of PDE5 by tadalafil leads to an increase in cGMP levels in the cavernous body of the penis. The result is a relaxation of smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs, cerebellum.

Cialis Com: CIALIS tablets - instructions for use, reviews, descriptions, analogues, release form, photo packaging, side effects, contraindications, price in pharmacies - Health Mail.ru

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The effect of tadalafil on PDE5 is more active than on other phosphodiesterase. Tadalafil is 10,000 times more active in relation to PDE5 than in relation to PDE1, PDE2, PDE4, which are localized in the heart, brain, blood vessels, liver, and other organs. Tadalafil is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE5, compared with PDE3, is important because PDE3 is an enzyme involved in the contraction of the heart muscle. In addition, tadalafil is approximately 700 times more active with respect to PDE5 than with respect to PDE6, which is found in the retina and is responsible for photo transmission. Tadalafil is also 10,000 times more active in relation to PDE5, compared with its effect on PDE7-PDE10.

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Effective for 36 hours. The effect appears already 16 minutes after ingestion in the presence of sexual arousal.

Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic pressure, compared with placebo in the supine position (the average maximum reduction is 1.6 / 0.8 mm Hg, respectively) and standing (the average maximum reduction is 0.2 / 4.6 mm Hg). respectively). Tadalafil does not cause significant changes in heart rate.

Tadalafil does not cause color recognition changes (blue / green) due to its low affinity for PDE6. In addition, no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size is noted.

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There was no clinically significant effect on sperm characteristics in men who took tadalafil at daily doses for 6 months.

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