Cialis - June 17, 2019

Cialis Coupon Cvs: Cialis instructions for use of indications, contraindications, side effects description Cialis tab., Pokr. film shell, 20 mg 1, 2, 4 or 8 pcs. (2904) – Handbook of drugs and drugs

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Cialis Coupon Cvs: Cialis instructions for use of indications, contraindications, side effects description Cialis tab., Pokr. film shell, 20 mg 1, 2, 4 or 8 pcs. (2904) - Handbook of drugs and drugs

Cialis instructions for use: indications, contraindications, side effects – a description of Cialis tab., Pokr. film cover, 20 mg: 1, 2, 4 or 8 pieces. (2904) – Handbook of drugs and drugs

Cialis tab. film coated, 20 mg. (2904) Indications, contraindications, dosing regimen, side effects, overdose, drug interactions. ELI LILLY VOSTOK, produced by ELI LILLY & Company

Excipients: lactose monohydrate – 245.195 mg, hyprolosis (hydroxypropylcellulose) – 8.05 mg, croscarmellose sodium – 22.4 mg, microcrystalline cellulose – 52.5 mg, magnesium stearate – 0.875 mg, sodium lauryl sulfate – 0.98 mg.

The composition of the film shell: Opadry II yellow (lactose monohydrate, hypromellose, titanium dioxide, triacetin, iron dye yellow oxide) – 14 mg.

1 PC. – blisters (1) – packs cardboard.

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2 pcs. – blisters (1) – packs cardboard.

2 pcs. – blisters (2) – packs cardboard.

2 pcs. – blisters (4) – packs cardboard.

Clinico-pharmacological group:

Drug for the treatment of erectile dysfunction. PDE5 inhibitor

Pharmaco-therapeutic group:

The treatment of erectile dysfunction, PDE-5 inhibitor

pharmachologic effect

The treatment for erectile dysfunction is a reversible selective inhibitor of specific PDE5 cGMP. When sexual arousal causes a local release of nitric oxide, the inhibition of PDE5 by tadalafil leads to an increase in cGMP levels in the cavernous body of the penis. The result is a relaxation of smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

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In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs, cerebellum.

Cialis Coupon Cvs: Cialis instructions for use of indications, contraindications, side effects description Cialis tab., Pokr. film shell, 20 mg 1, 2, 4 or 8 pcs. (2904) - Handbook of drugs and drugs

The effect of tadalafil on PDE5 is more active than on other phosphodiesterase. Tadalafil is 10,000 times more active in relation to PDE5 than in relation to PDE1, PDE2, PDE4, which are localized in the heart, brain, blood vessels, liver, and other organs. Tadalafil is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE5, compared with PDE3, is important because PDE3 is an enzyme involved in the contraction of the heart muscle. In addition, tadalafil is approximately 700 times more active with respect to PDE5 than with respect to PDE6, which is found in the retina and is responsible for photo transmission. Tadalafil is also 10,000 times more active in relation to PDE5, compared with its effect on PDE7-PDE10.

Effective for 36 hours. The effect appears already 16 minutes after ingestion in the presence of sexual arousal.

Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic pressure, compared with placebo in the supine position (the average maximum reduction is 1.6 / 0.8 mm Hg, respectively) and standing (the average maximum reduction is 0.2 / 4.6 mm Hg). respectively). Tadalafil does not cause significant changes in heart rate.

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Tadalafil does not cause color recognition changes (blue / green) due to its low affinity for PDE6. In addition, no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size is noted.

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There was no clinically significant effect on sperm characteristics in men who took tadalafil at daily doses for 6 months.

Pharmacokinetics

After oral administration, tadalafil is rapidly absorbed. Cmax is achieved on average after 2 hours. The speed and extent of absorption does not depend on food intake. The pharmacokinetics of tadalafil in healthy individuals is linear with respect to time and dose. In the dose range from 2.5 to 20 mg, AUC increases in proportion to the dose. Css in plasma is achieved within 5 days while taking the drug 1 time / day.

The pharmacokinetics of tadalafil in patients with dysfunction of erection is similar to the pharmacokinetics of the drug in individuals without dysfunction of erection.

Vd is about 63 liters, which indicates that tadalafil is distributed in body tissues. At therapeutic concentrations, 94% of tadalafil binds to plasma proteins. In healthy individuals, less than 0.0005% of the administered dose was detected in semen.

Metabolized with the participation of the isoenzyme CYP3A4. The main circulating metabolite is methylcateholglucuronide, which is 13,000 times less active in relation to PDE5 than tadalafil, therefore it is unlikely that this metabolite is clinically significant.

In healthy individuals, the average clearance of tadalafil on ingestion is 2.5 l / h, and the average T1 / 2 is 17.5 hours. Tadalafil is eliminated mainly as inactive metabolites, mainly with feces (about 61%) and to a lesser extent with urine (about 36%). %).

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In patients with mild renal failure (CC from 51 to 80 ml / min) or moderate severity (CC from 31 to 50 ml / min), AUC is greater than in healthy individuals.

Indications of the drug

Erectile dysfunction.

ICD-10 codes

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